TY  - JOUR
N1  - Copyright of this article belongs to Oxford University Press (OUP)
ID  - open3489
UR  - https://pubmed.ncbi.nlm.nih.gov/41488976/
IS  - 5
A1  - Vuyyuru, Sudheer Kumar
A1  - Singh, Urvashi
A1  - Das, Prasenjit
A1  - Basant, Shiv
A1  - Singh, Vishwajeet
A1  - Sinha, Saroj Kant
A1  - Sharma, Kusum
A1  - Ramakrishnan, B S
A1  - Palaniyandi, Kannan
A1  - Pokharna, Rupesh
A1  - Malhotra, Bharti
A1  - Bhatia, Shobna
A1  - Dhali, Gopal Krishna
A1  - Sarkar, Rajib
A1  - Sharma, Charu
A1  - Dattagupta, Siddhartha
A1  - Singh, Manjula
A1  - Kochhar, Rakesh
A1  - Vishnubhatla, Sreenivas
A1  - Ahuja, Vineet
Y1  - 2026/05/20/
N2  - BackgroundThe causal relationship between Crohn's disease (CD) and Mycobacterium avium subspecies paratuberculosis (MAP) remains controversial.MethodsThis multicenter observational study was conducted across seven tertiary care centers in India enrolled newly diagnosed, treatment-na\"\ive Crohn's disease (CD) patients as cases, and treatment-na\"\ive intestinal tuberculosis (ITB), ulcerative colitis (UC), and healthy individuals undergoing sigmoidoscopy for hemorrhoids as controls. Mycobacterium avium subspecies paratuberculosis (MAP) detection was performed using serology for MAP antibodies, PCR, RT-qPCR, and solid/liquid cultures on blood and colonic biopsies. In situ PCR and immunohistochemistry (IHC) were additionally applied to paraffin-embedded tissue sections to evaluate MAP presence across groups.FindingsA total of 889 participants were recruited (CD=148, ITB=288, UC=251 and non-IBD controls=202) were included. The seropositivity of MAP was significantly higher in patients with CD compared to controls (20.6% 13/63 vs healthy controls: 16.2\% 12/74; ITB: 7.8\% 9/116; UC: 4.8\% 4/84; pInterpretationFindings of our study suggest an increased association of MAP and CD. Future studies should explore possible causal role of MAP in CD and potential therapeutic options to target MAP.
PB  - Oxford University Press (OUP)
JF  - Clin. Infect. Dis.
VL  - 82
KW  - Mycobacterium avium paratuberculosis ; Crohn's disease; intestinal tuberculosis; ulcerative colitis
TI  - Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region
SP  - 841
EP  - 847
ER  -