@article{open361,
          volume = {111},
          number = {1},
           month = {January},
          author = {A V Shaji and S K Kulkarni and J N Agrewala},
            note = {copyright of this article belongs Blackwell/Oxford},
           title = {Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells.},
       publisher = {Blackwell Science / Oxford},
            year = {1998},
         journal = {Clinical and experimental immunology},
           pages = {181--5},
        keywords = {melatonin;T cell;IL-4 and IgG1},
             url = {http://crdd.osdd.net/open/361/},
        abstract = {In the present study, we describe the potential role of melatonin, a pineal hormone, in regulating the activation of the antigen-specific T cell response. Melatonin encouraged the proliferation of Th cells and improved their ability to secrete IL-4, but down-regulated the levels of IL-2 and interferon-gamma (IFN-gamma). Melatonin, however, could not exert any influence on the T cells of unprimed mice. On studying the regulation of subclass of IgG isotype, melatonin specifically enhanced the secretion of antigen-specific IgG1 antibodies and decreased the yield of IgG2a isotype. The results suggest that melatonin possibly acts by selectively activating a Th2-like immune response.}
}