title: Antigen incorporation into liposomes results in the enhancement of IL-4 and IgG1 secretion: evidence for preferential expansion of Th-2 cells.
creator: Agrewala, J N
creator: Owais, M
creator: Gupta, C M
creator: Mishra, G C
subject: QR180 Immunology
description: Liposomes have been used to modify the immunological behaviour of a number of antigens. The present study was designed to evaluate the effect of liposomization of ovalbumin on the induction of Th-1 and Th-2-cell response by monitoring the secretion of lymphokines and IgG Isotypes. Liposomes having varied physicochemical properties (positively and negatively charged, neutral and pH-sensitive) were used for this purpose. Ovalbumin delivered in this way induced preferential secretion of IL-4 and production of antigen-specific IgG1 isotypes. This was observed irrespective of the surface charge properties of the liposomes. Further, the concentration of antigen required for the activation of Th cells was 10(2)- to 10(3)-fold lower after encapsulating it in liposomes. These results suggest that liposomes may prove useful adjuvants to prime Th2-like immune responses.
publisher: Martin Dunitz Publishers
date: 1996-03
type: Article
type: PeerReviewed
identifier:   Agrewala, J N and Owais, M and Gupta, C M and Mishra, G C  (1996) Antigen incorporation into liposomes results in the enhancement of IL-4 and IgG1 secretion: evidence for preferential expansion of Th-2 cells.  Cytokines and molecular therapy, 2 (1).  pp. 59-65.  ISSN 1355-6568     
relation: http://crdd.osdd.net/open/384/