<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "A 150-kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin-specific CD4+ T cells."^^ . "In the present study, we describe the potential co-stimulatory role of a macrophage membrane-associated protein of 150 kDa (M150). The protein was isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and was found to be a single molecule on two-dimensional gel electrophoresis. The molecule was re-constituted in phosphatidyl choline vesicles and tested for its ability to promote the proliferation and the secretion of lymphokines from T helper (Th) cells. The reconstituted M150 induced a significant proliferation of anti-CD3 monoclonal antibody (mAb)-stimulated ovalbumin-specific CD4+ T cells. Further, Th cells activated with this molecule in the presence of anti-CD3 mAb mainly secreted interleukin (IL)-2 and interferon-gamma but not IL-4. M150 could not promote the proliferation of Th cells, or lymphokine secretion in the absence of anti-CD3 mAb. These observations suggest that M150 acts by selectively activating a Th1-like immune response."^^ . "1994-09" . . "24" . "9" . . "Wiley"^^ . . . "European journal of immunology"^^ . . . "00142980" . . . . . . . . . . . . . . . . "D S"^^ . "Vinay"^^ . "D S Vinay"^^ . . "G C"^^ . "Mishra"^^ . "G C Mishra"^^ . . "A"^^ . "Joshi"^^ . "A Joshi"^^ . . "J N"^^ . "Agrewala"^^ . "J N Agrewala"^^ . . . . . . "A 150-kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin-specific CD4+ T cells. (PDF)"^^ . . . . "HTML Summary of #405 \n\nA 150-kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin-specific CD4+ T cells.\n\n" . "text/html" . . . "QR180 Immunology"@en . .