@article{open406,
          volume = {120},
          number = {3},
           month = {July},
          author = {S Majumder and R Gupta},
            note = {Copyright of this article belongs to Elsevier Science},
           title = {Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.},
       publisher = {Elsevier Science},
            year = {1994},
         journal = {FEMS microbiology letters},
           pages = {329--34},
        keywords = {Mycobacterium microti; Interleukin-1 a; Mycobacteria; Cyclic AMP},
             url = {http://crdd.osdd.net/open/406/},
        abstract = {The effect of mouse recombinant interleukin-1 alpha on the intracellular growth of Mycobacterium microti in a murine macrophage cell line J774A.1 was investigated. Interleukin-1 alpha added after infection to the M. microti-infected macrophage monolayers enhanced the growth of M. microti in a concentration-dependent manner and this growth enhancement was abrogated by neutralization of interleukin-1 alpha with anti-interleukin-1 alpha antibody. Cyclic adenosine monophosphate level in J774A.1 cells was increased by the addition of interleukin-1 alpha. Addition of dibutyryl cyclic adenosine monophosphate to infected J774A.1 cells increased the number of intracellular bacteria in a concentration-dependent manner. These results suggest that interleukin-1 alpha acts as a growth enhancer for intracellular M. microti and the growth enhancing effect of interleukin-1 alpha may be due to enhanced cellular cyclic adenosine monophosphate level.}
}