title: Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.
creator: Majumder, S
creator: Gupta, R
subject: QR Microbiology
description: The effect of mouse recombinant interleukin-1 alpha on the intracellular growth of Mycobacterium microti in a murine macrophage cell line J774A.1 was investigated. Interleukin-1 alpha added after infection to the M. microti-infected macrophage monolayers enhanced the growth of M. microti in a concentration-dependent manner and this growth enhancement was abrogated by neutralization of interleukin-1 alpha with anti-interleukin-1 alpha antibody. Cyclic adenosine monophosphate level in J774A.1 cells was increased by the addition of interleukin-1 alpha. Addition of dibutyryl cyclic adenosine monophosphate to infected J774A.1 cells increased the number of intracellular bacteria in a concentration-dependent manner. These results suggest that interleukin-1 alpha acts as a growth enhancer for intracellular M. microti and the growth enhancing effect of interleukin-1 alpha may be due to enhanced cellular cyclic adenosine monophosphate level.
publisher: Elsevier Science
date: 1994-07-15
type: Article
type: PeerReviewed
format: application/pdf
identifier: http://crdd.osdd.net/open/406/1/majumdar94.pdf
relation: http://www.sciencedirect.com/science/article/pii/0378109794904928
identifier:   Majumder, S and Gupta, R  (1994) Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.  FEMS microbiology letters, 120 (3).  pp. 329-34.  ISSN 0378-1097     
relation: http://crdd.osdd.net/open/406/