creators_name: Majumder, S
creators_name: Gupta, R
type: article
datestamp: 2011-12-13 16:51:49
lastmod: 2011-12-13 16:51:49
metadata_visibility: show
title: Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.
ispublished: pub
subjects: QR
full_text_status: restricted
keywords: Mycobacterium microti; Interleukin-1 a; Mycobacteria; Cyclic AMP
note: Copyright of this article belongs to Elsevier Science
abstract: The effect of mouse recombinant interleukin-1 alpha on the intracellular growth of Mycobacterium microti in a murine macrophage cell line J774A.1 was investigated. Interleukin-1 alpha added after infection to the M. microti-infected macrophage monolayers enhanced the growth of M. microti in a concentration-dependent manner and this growth enhancement was abrogated by neutralization of interleukin-1 alpha with anti-interleukin-1 alpha antibody. Cyclic adenosine monophosphate level in J774A.1 cells was increased by the addition of interleukin-1 alpha. Addition of dibutyryl cyclic adenosine monophosphate to infected J774A.1 cells increased the number of intracellular bacteria in a concentration-dependent manner. These results suggest that interleukin-1 alpha acts as a growth enhancer for intracellular M. microti and the growth enhancing effect of interleukin-1 alpha may be due to enhanced cellular cyclic adenosine monophosphate level.
date: 1994-07-15
date_type: published
publication: FEMS microbiology letters
volume: 120
number: 3
publisher: Elsevier Science
pagerange: 329-34
refereed: TRUE
issn: 0378-1097
official_url: http://www.sciencedirect.com/science/article/pii/0378109794904928
related_url_url: http://www.sciencedirect.com/science/article/pii/0378109794904928
related_url_type: pub
citation:   Majumder, S and Gupta, R  (1994) Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.  FEMS microbiology letters, 120 (3).  pp. 329-34.  ISSN 0378-1097     
document_url: http://crdd.osdd.net/open/406/1/majumdar94.pdf