title: Biotransformations of rifamycins: process possibilities.
creator: Banerjee, U C
creator: Saxena, B
creator: Chisti, Y.
subject: QD Chemistry
description: Rifampicin, an important antibiotic, is manufactured by chemical conversion of rifamycin S which is obtained by the chemical modification of rifamycin B. Rifamycin B is a product of Nocardia mediterranei fermentations. The chemical conversion of rifamycin B to rifamycin S has many disadvantages: Strong acidic conditions are required, heavy foam formation accompanies transformation and the yields are low. This review highlights the developments in alternative, biochemical transformations using enzymes and cells; the main focus is on transformations carried out by rifamycin oxidase.
publisher: Elsevier Science
date: 1992
type: Article
type: PeerReviewed
format: application/pdf
identifier: http://crdd.osdd.net/open/425/1/banerjee92.pdf
relation: http://www.sciencedirect.com/science/article/pii/073497509291454M
identifier:   Banerjee, U C and Saxena, B and Chisti, Y.  (1992) Biotransformations of rifamycins: process possibilities.  Biotechnology advances, 10 (4).  pp. 577-95.  ISSN 0734-9750     
relation: http://crdd.osdd.net/open/425/