TY  - JOUR
N1  - Copyright of this article belongs to Elsevier Science
ID  - open425
UR  - http://www.sciencedirect.com/science/article/pii/073497509291454M
IS  - 4
A1  - Banerjee, U C
A1  - Saxena, B
A1  - Chisti, Y.
Y1  - 1992///
N2  - Rifampicin, an important antibiotic, is manufactured by chemical conversion of rifamycin S which is obtained by the chemical modification of rifamycin B. Rifamycin B is a product of Nocardia mediterranei fermentations. The chemical conversion of rifamycin B to rifamycin S has many disadvantages: Strong acidic conditions are required, heavy foam formation accompanies transformation and the yields are low. This review highlights the developments in alternative, biochemical transformations using enzymes and cells; the main focus is on transformations carried out by rifamycin oxidase.
PB  - Elsevier Science
JF  - Biotechnology advances
VL  - 10
SN  - 0734-9750
TI  - Biotransformations of rifamycins: process possibilities.
SP  - 577
AV  - restricted
EP  - 95
ER  -