creators_name: Banerjee, U C
creators_name: Saxena, B
creators_name: Chisti, Y.
type: article
datestamp: 2011-12-12 15:38:29
lastmod: 2012-03-29 06:48:03
metadata_visibility: show
title: Biotransformations of rifamycins: process possibilities.
ispublished: pub
subjects: QD
full_text_status: restricted
note: Copyright of this article belongs to Elsevier Science
abstract: Rifampicin, an important antibiotic, is manufactured by chemical conversion of rifamycin S which is obtained by the chemical modification of rifamycin B. Rifamycin B is a product of Nocardia mediterranei fermentations. The chemical conversion of rifamycin B to rifamycin S has many disadvantages: Strong acidic conditions are required, heavy foam formation accompanies transformation and the yields are low. This review highlights the developments in alternative, biochemical transformations using enzymes and cells; the main focus is on transformations carried out by rifamycin oxidase.
date: 1992
date_type: published
publication: Biotechnology advances
volume: 10
number: 4
publisher: Elsevier Science
pagerange: 577-95
refereed: TRUE
issn: 0734-9750
official_url: http://www.sciencedirect.com/science/article/pii/073497509291454M
citation:   Banerjee, U C and Saxena, B and Chisti, Y.  (1992) Biotransformations of rifamycins: process possibilities.  Biotechnology advances, 10 (4).  pp. 577-95.  ISSN 0734-9750     
document_url: http://crdd.osdd.net/open/425/1/banerjee92.pdf