%A Sandro Vivona
%A Jennifer L Gardy
%A Srinivasan Ramachandran
%A Fiona S L Brinkman
%A G.P.S. Raghava
%A Darren R Flower
%A Francesco Filippini
%O Copyright of this articlebelongs to Elsevier Science.
%J Trends in biotechnology
%T Computer-aided biotechnology: from immuno-informatics to reverse vaccinology.
%X Genome sequences from many organisms, including humans, have been completed, and high-throughput analyses have produced burgeoning volumes of 'omics' data. Bioinformatics is crucial for the management and analysis of such data and is increasingly used to accelerate progress in a wide variety of large-scale and object-specific functional analyses. Refined algorithms enable biotechnologists to follow 'computer-aided strategies' based on experiments driven by high-confidence predictions. In order to address compound problems, current efforts in immuno-informatics and reverse vaccinology are aimed at developing and tuning integrative approaches and user-friendly, automated bioinformatics environments. This will herald a move to 'computer-aided biotechnology': smart projects in which time-consuming and expensive large-scale experimental approaches are progressively replaced by prediction-driven investigations.
%N 4
%P 190-200
%V 26
%D 2008
%I Elsevier Science
%L open43