title: Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.
creator: Mishra, Nitish K
creator: Agarwal, Sandhya
creator: Raghava, G.P.S.
subject: QR Microbiology
description: This study demonstrates that SVM based QSAR model can predict substrate specificity of major CYP isoforms with high accuracy. These models can be used to predict isoform responsible for metabolizing a drug molecule. Thus these models can used to understand whether a molecule will be metabolized or not. This is possible to develop highly accurate models for predicting substrate specificity of major isoforms using CDK descriptors. A web server MetaPred has been developed for predicting metabolizing isoform of a drug molecule http://crdd.osdd.net/raghava/metapred/.
publisher: BIomedcentral
date: 2010
type: Article
type: PeerReviewed
format: application/pdf
identifier: http://crdd.osdd.net/open/504/1/raghava10.9.pdf
relation: http://www.biomedcentral.com/content/pdf/1471-2210-10-8.pdf
identifier:   Mishra, Nitish K and Agarwal, Sandhya and Raghava, G.P.S.  (2010) Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.  BMC pharmacology, 10.  p. 8.  ISSN 1471-2210     
relation: http://crdd.osdd.net/open/504/