%0 Journal Article
%@ 1471-2210
%A Mishra, Nitish K
%A Agarwal, Sandhya
%A Raghava, G.P.S.
%D 2010
%F open:504
%I BIomedcentral
%J BMC pharmacology
%P 8
%T Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.
%U http://crdd.osdd.net/open/504/
%V 10
%X This study demonstrates that SVM based QSAR model can predict substrate specificity of major CYP isoforms with high accuracy. These models can be used to predict isoform responsible for metabolizing a drug molecule. Thus these models can used to understand whether a molecule will be metabolized or not. This is possible to develop highly accurate models for predicting substrate specificity of major isoforms using CDK descriptors. A web server MetaPred has been developed for predicting metabolizing isoform of a drug molecule http://crdd.osdd.net/raghava/metapred/.
%Z OPEN ACCESS