creators_name: Mishra, Nitish K
creators_name: Agarwal, Sandhya
creators_name: Raghava, G.P.S.
type: article
datestamp: 2011-12-08 18:59:26
lastmod: 2011-12-13 17:14:09
metadata_visibility: show
title: Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.
ispublished: pub
subjects: QR
full_text_status: public
note: OPEN ACCESS
abstract: This study demonstrates that SVM based QSAR model can predict substrate specificity of major CYP isoforms with high accuracy. These models can be used to predict isoform responsible for metabolizing a drug molecule. Thus these models can used to understand whether a molecule will be metabolized or not. This is possible to develop highly accurate models for predicting substrate specificity of major isoforms using CDK descriptors. A web server MetaPred has been developed for predicting metabolizing isoform of a drug molecule http://crdd.osdd.net/raghava/metapred/.
date: 2010
date_type: published
publication: BMC pharmacology
volume: 10
publisher: BIomedcentral
pagerange: 8
refereed: TRUE
issn: 1471-2210
official_url: http://www.biomedcentral.com/content/pdf/1471-2210-10-8.pdf
related_url_url: http://crdd.osdd.net/raghava/metapred/
related_url_type: org
citation:   Mishra, Nitish K and Agarwal, Sandhya and Raghava, G.P.S.  (2010) Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.  BMC pharmacology, 10.  p. 8.  ISSN 1471-2210     
document_url: http://crdd.osdd.net/open/504/1/raghava10.9.pdf