creators_name: Gowthaman, Uthaman
creators_name: Chodisetti, Sathi Babu
creators_name: Agrewala, J N
type: article
datestamp: 2011-12-08 18:59:42
lastmod: 2015-01-07 04:57:41
metadata_visibility: show
title: T cell help to B cells in germinal centers: putting the jigsaw together.
ispublished: pub
subjects: QR180
full_text_status: none
keywords: follicular T helper cells; B cells, germinal centers; T cell subsets
note: Copyright of this article belongs to Informa Healthcare
abstract: The germinal center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4(+) T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4(+) T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.
date: 2010-08
date_type: published
publication: International reviews of immunology
volume: 29
number: 4
publisher: Informa healthcare
pagerange: 403-20
refereed: TRUE
issn: 1563-5244
official_url: http://informahealthcare.com/doi/abs/10.3109/08830185.2010.496503
related_url_url: http://informahealthcare.com/doi/abs/10.3109/08830185.2010.496503
related_url_type: pub
citation:   Gowthaman, Uthaman and Chodisetti, Sathi Babu and Agrewala, J N  (2010) T cell help to B cells in germinal centers: putting the jigsaw together.  International reviews of immunology, 29 (4).  pp. 403-20.  ISSN 1563-5244