<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Global structure of HIV-1 neutralizing antibody IgG1 b12 is asymmetric."^^ . "Human antibody IgG1 b12 is one of the four antibodies known to neutralize a broad range of human immunodeficiency virus-1. The crystal structure of this antibody displayed an asymmetric disposition of the Fab arms relative to its Fc portion. Comparison of structures solved for other IgG1 antibodies led to a notion that crystal packing forces entrapped a \"snap-shot\" of different conformations accessible to this antibody. To elucidate global structure of this unique antibody, we acquired small-angle X-ray scattering data from its dilute solution. Data analysis indicated that b12 adopts a bilobal globular structure in solution with a radius of gyration and a maximum linear dimension of approximately 54 and approximately 180A, respectively. Extreme similarity between its solution and crystal structure concludes that non-flexible, asymmetric shape is an inherent property of this rare antibody."^^ . "2010-01-01" . "391" . "1" . . "Elsevier Science"^^ . . . "Biochemical and biophysical research communications"^^ . . . "10902104" . . . . . . . . . . . . . . . . "Joanna K"^^ . "Krueger"^^ . "Joanna K Krueger"^^ . . "Ashish K"^^ . "Solanki"^^ . "Ashish K Solanki"^^ . . "Christopher D"^^ . "Boone"^^ . "Christopher D Boone"^^ . . "Ashish"^^ . "Ganguly"^^ . "Ashish Ganguly"^^ . . . . . "HTML Summary of #541 \n\nGlobal structure of HIV-1 neutralizing antibody IgG1 b12 is asymmetric.\n\n" . "text/html" . . . "QD Chemistry"@en . .