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primary topic: Prediction and classification of chemokines and their receptors.

Prediction and classification of chemokines and their receptors.
type: AcademicArticle
type: Article
abstract: Chemokines are low molecular mass cytokine-like proteins that orchestrate myriads of immune functions like leukocyte trafficking, T cell differentiation, angiogenesis, hematopeosis and mast cell degranulation. Chemokines also play a role as HIV-1 inhibitor and act as potent natural adjuvant in antitumor immunotherapy. Receptors for these molecules are all seven-pass transmembrane G-protein-coupled receptors that are intimately involved with chemokines in a wide array of physiological and pathological conditions. These receptors also have a major role as co-receptors for HIV-1 entry into target cells. Therefore, chemokine receptors have proven to be excellent targets for small molecule in pharmaceutical industry. The immense importance of chemokines and their receptors motivated us to develop a support vector machine-based method ChemoPred to predict this important class of proteins and further classify them into subfamilies. ChemoPred is capable of predicting chemokines and chemokine receptors with an accuracy of 95.08% and 92.19%, respectively. The overall accuracy of classification of chemokines into three subfamilies was 96.00% and that of chemokine receptors into three families was 92.87%. The server ChemoPred is freely available at www.imtech.res.in/raghava/chemopred.
date: 2009-07
volume: 22
issue: 7
is part of: Protein engineering, design & selection : PEDS
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Prediction and classification of chemokines and their receptors. (PDF)
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subject: Biotechnology

Prediction and classification of chemokines and their receptors. (PDF)
type: Document

Oxford University Press
type: Organization

Protein engineering, design & selection : PEDS
type: Collection
issn: 17410134

G.P.S. Raghava
type: Person
given name: G.P.S.
family name: Raghava

Sneh Lata
type: Person
given name: Sneh
family name: Lata

Prediction and classification of chemokines and their receptors. (Image (PNG))
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Prediction and classification of chemokines and their receptors. (Indexer Terms)
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primary topic: Prediction and classification of chemokines and their receptors.

Biotechnology
type: Concept
preferred label: QH301 Biology