creators_name: Bhasin, Manoj
creators_name: Lata, Sneh
creators_name: Raghava, G.P.S.
type: article
datestamp: 2011-12-08 19:39:51
lastmod: 2011-12-08 19:39:51
metadata_visibility: show
title: TAPPred prediction of TAP-binding peptides in antigens.
ispublished: pub
subjects: QH301
full_text_status: restricted
note: Copyright of this article belongs to Springer Science
abstract: The transporter associated with antigen processing (TAP) plays a crucial role in the transport of the peptide fragments of the proteolysed antigenic or self-altered proteins to the endoplasmic reticulum where the association between these peptides and the major histocompatibility complex (MHC) class I molecules takes place. Therefore, prediction of TAP-binding peptides is highly helpful in identifying the MHC class I-restricted T-cell epitopes and hence in the subunit vaccine designing. In this chapter, we describe a support vector machine (SVM)-based method TAPPred that allows users to predict TAP-binding affinity of peptides over web. The server allows user to predict TAP binders using a simple SVM model or cascade SVM model. The server also allows user to customize the display/output. It is freely available for academicians and noncommercial organization at the address http://www.imtech.res.in/raghava/tappred.
date: 2007
date_type: published
publication: Methods in molecular biology (Clifton, N.J.)
volume: 409
publisher: Springer Science
pagerange: 381-6
refereed: TRUE
issn: 1064-3745
official_url: http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-60327-118-9_28
related_url_url: http://www.imtech.res.in/raghava/tappred. 
related_url_type: org
citation:   Bhasin, Manoj and Lata, Sneh and Raghava, G.P.S.  (2007) TAPPred prediction of TAP-binding peptides in antigens.  Methods in molecular biology (Clifton, N.J.), 409.  pp. 381-6.  ISSN 1064-3745     
document_url: http://crdd.osdd.net/open/596/1/raghavaproto1.pdf