title: Searching and mapping of T-cell epitopes, MHC binders, and TAP binders.
creator: Bhasin, Manoj
creator: Lata, Sneh
creator: Raghava, G.P.S.
subject: QR180 Immunology
description: This chapter describes searching and mapping tools of MHCBN database, which is a curated database. It comprises over 23,000 peptide sequences, whose binding affinity with major histocompatibility complex (MHC) or transporter associated with antigen processing (TAP) molecules has been assayed experimentally. Each entry of the database provides full information (such as sequence, its MHC- or TAP-binding specificity, and source protein) about peptide whose binding affinity (IC50) and T-cell activity is experimentally determined. MHCBN has number of web-based tools for analyzing and retrieving information. In this chapter, we describe how to use web tools integrated in MHCBN that include (i) mapping of experimentally determined antigenic regions on the query sequence, (ii) creation of allele-specific peptide data set, and (iii) BLAST search against MHC or antigen databases.
publisher: Springer Science
date: 2007
type: Article
type: PeerReviewed
format: application/pdf
identifier: http://crdd.osdd.net/open/61/1/raghava2007.pdf
relation: http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-60327-118-9_6
identifier:   Bhasin, Manoj and Lata, Sneh and Raghava, G.P.S.  (2007) Searching and mapping of T-cell epitopes, MHC binders, and TAP binders.  Methods in molecular biology (Clifton, N.J.), 409.  pp. 95-112.  ISSN 1064-3745     
relation: http://crdd.osdd.net/open/61/