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primary topic: Structural biology, protein conformations and drug designing.

Structural biology, protein conformations and drug designing.
type: AcademicArticle
type: Article
abstract: Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledge of structure based functional properties of a drug target is very essential for a successful in silico designing of drugs. However, some problems associated with the structure determination process and lack of knowledge of conformational freedom associated with available protein structures are the hurdles involved in structure based drug designing. Docking and virtual screening processes depend on the active site structure of the receptor molecule and subtle differences in the conformations of these molecules due to flexibility pose a serious threat to the drug designing process. In this review problems associated with the conformations of proteins and homology models was reviewed.
date: 2007-08
volume: 8
issue: 4
is part of: Current protein & peptide science
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
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subject: QR Microbiology

Structural biology, protein conformations and drug designing. (PDF)
type: Document

Bentham Science
type: Organization

Current protein & peptide science
type: Collection
issn: 13892037

K V Radha Kishan
type: Person
given name: K V Radha
family name: Kishan

Structural biology, protein conformations and drug designing. (Indexer Terms)
type: Document
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primary topic: Structural biology, protein conformations and drug designing.

QR Microbiology
type: Concept