creators_name: Kishan, K V Radha
type: article
datestamp: 2011-11-30 05:10:39
lastmod: 2011-11-30 05:10:58
metadata_visibility: show
title: Structural biology, protein conformations and drug designing.
ispublished: pub
subjects: QR
full_text_status: restricted
note: Copyright of this article belongs to Bentham Science
abstract: Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledge of structure based functional properties of a drug target is very essential for a successful in silico designing of drugs. However, some problems associated with the structure determination process and lack of knowledge of conformational freedom associated with available protein structures are the hurdles involved in structure based drug designing. Docking and virtual screening processes depend on the active site structure of the receptor molecule and subtle differences in the conformations of these molecules due to flexibility pose a serious threat to the drug designing process. In this review problems associated with the conformations of proteins and homology models was reviewed.
date: 2007-08
date_type: published
publication: Current protein & peptide science
volume: 8
number: 4
publisher: Bentham Science
pagerange: 376-80
refereed: TRUE
issn: 1389-2037
official_url: http://www.benthamdirect.org/pages/b_viewarticle.php
related_url_url: http://www.benthamdirect.org/pages/b_viewarticle.php
related_url_type: pub
citation:   Kishan, K V Radha  (2007) Structural biology, protein conformations and drug designing.  Current protein & peptide science, 8 (4).  pp. 376-80.  ISSN 1389-2037     
document_url: http://crdd.osdd.net/open/628/1/radha2007.pdf