TY  - JOUR
N1  - Copyright of this article belongs to Springer Science.
ID  - open700
UR  - http://dx.doi.org/10.1007/BF00420437
IS  - 2
A1  - Patnaik, P R
Y1  - 1995///
N2  - Previous studies have shown that the rate of formation of streptokinase, a secondary metabolite, in batch fermentation is proportional to the specific growth rate of the biomass, which in turn is inhibited by its substrate and the primary product (lactic acid). These kinetics suggest the suitability of fed-batch operation to increase the yield of streptokinase. A near-optimal feed policy has been calculated by the chemotaxis algorithm, and it shows a substrate feed rate decreasing nonlinearly and vanishing after 11 hours. This is followed by batch fermentation for a further 8 hours, at the end of which 12% more streptokinase is generated than by purely batch fermentation. Further improvements in productivity are possible.
PB  - Springer Science
JF  - Bioprocess Engineering
VL  - 13
SN  - 0178-515X
TI  - A heuristic approach to fed-batch optimisation of streptokinase fermentation
SP  - 109
AV  - none
EP  - 112
ER  -