creators_name: Patnaik, P R
type: article
datestamp: 2012-01-27 15:34:40
lastmod: 2015-01-12 04:17:23
metadata_visibility: show
title: A heuristic approach to fed-batch optimisation of streptokinase fermentation
ispublished: pub
subjects: QR
full_text_status: none
note: Copyright of this article belongs to Springer Science.
abstract: Previous studies have shown that the rate of formation of streptokinase, a secondary metabolite, in batch fermentation is proportional to the specific growth rate of the biomass, which in turn is inhibited by its substrate and the primary product (lactic acid). These kinetics suggest the suitability of fed-batch operation to increase the yield of streptokinase. A near-optimal feed policy has been calculated by the chemotaxis algorithm, and it shows a substrate feed rate decreasing nonlinearly and vanishing after 11 hours. This is followed by batch fermentation for a further 8 hours, at the end of which 12% more streptokinase is generated than by purely batch fermentation. Further improvements in productivity are possible.
date: 1995
date_type: published
publication: Bioprocess Engineering
volume: 13
number: 2
publisher: Springer Science
pagerange: 109-112
id_number: doi:10.1007/BF00420437
refereed: TRUE
issn: 0178-515X
official_url: http://dx.doi.org/10.1007/BF00420437
related_url_url: http://www.springerlink.com/content/th7553v82878h668/
related_url_type: pub
citation:   Patnaik, P R  (1995) A heuristic approach to fed-batch optimisation of streptokinase fermentation.  Bioprocess Engineering, 13 (2).  pp. 109-112.  ISSN 0178-515X     
document_url: http://crdd.osdd.net/open/700/1/pat95%28s4%29.pdf