@article{open706,
          volume = {153},
          number = {4},
           month = {August},
          author = {L Vijayakrishnan and V Kumar and J N Agrewala and G C Mishra and K V Rao},
            note = {Copyright of this article belongs to American Association of Immunologists.},
           title = {Antigen-specific early primary humoral responses modulate immunodominance of B cell epitopes.},
       publisher = {American Association of Immunologists},
            year = {1994},
         journal = {Journal of immunology (Baltimore, Md. : 1950)},
           pages = {1613--25},
             url = {http://crdd.osdd.net/open/706/},
        abstract = {Accumulation of primary Abs against two distinct epitopes on a designed polypeptide, MEP-1, was examined. The early primary response was predominantly against a C-terminal epitope (MEP 77-100), although subsequent maturation established an epitope within the N-terminal half (MEP 17-31) as the immunodominant one. Inversion of immunodominance correlated with the inability of anti-MEP 77-100 B cells to interact productively with T cells, which consequently received reduced help. Interaction between epitope-specific B and T cells was found to be attenuated in the presence of early primary anti-MEP-1 antiserum, and the extent of inhibition was directly proportional to the level and affinity of epitope-specific Igs. Therefore, it seems that early primary Abs to a multideterminant Ag selectively down-regulate maturation of epitope-specific primary humoral responses.}
}