TY  - JOUR
N1  - Copyright of this article belongs to American Association of Immunologists.
ID  - open706
UR  - http://www.jimmunol.org/content/153/4/1613.long
IS  - 4
A1  - Vijayakrishnan, L
A1  - Kumar, V
A1  - Agrewala, J N
A1  - Mishra, G C
A1  - Rao, K V
Y1  - 1994/08/15/
N2  - Accumulation of primary Abs against two distinct epitopes on a designed polypeptide, MEP-1, was examined. The early primary response was predominantly against a C-terminal epitope (MEP 77-100), although subsequent maturation established an epitope within the N-terminal half (MEP 17-31) as the immunodominant one. Inversion of immunodominance correlated with the inability of anti-MEP 77-100 B cells to interact productively with T cells, which consequently received reduced help. Interaction between epitope-specific B and T cells was found to be attenuated in the presence of early primary anti-MEP-1 antiserum, and the extent of inhibition was directly proportional to the level and affinity of epitope-specific Igs. Therefore, it seems that early primary Abs to a multideterminant Ag selectively down-regulate maturation of epitope-specific primary humoral responses.
PB  - American Association of Immunologists
JF  - Journal of immunology (Baltimore, Md. : 1950)
VL  - 153
SN  - 0022-1767
TI  - Antigen-specific early primary humoral responses modulate immunodominance of B cell epitopes.
SP  - 1613
AV  - restricted
EP  - 25
ER  -