%0 Journal Article
%@ 1019-6439 
%A Bhui, AJ
%A Bureau, J
%A Abbas, A
%A Mondal, A
%D 1996
%F open:751
%I PROFESSOR D A SPANDIDOS, EDITORIAL OFFICE, 1, S MERKOURI ST, ATHENS 116 35, GREECE 
%J INTERNATIONAL JOURNAL OF ONCOLOGY
%N 4
%P 669-677
%T Novel cellular markers in breast cancer: Differential presence of p23K and p30.33K prosomal antigens in tumors of Parsi and non-Parsi women.
%U http://crdd.osdd.net/open/751/
%V 9
%X Epidemiological studies have revealed that Parsi women have a higher incidence of breast cancer than non-Parsis and that they are more susceptible to breast cancer. We have studied the cellular distribution of two prosomal proteins p23K in parallel to the p30.33K and proliferation marker Ki-67 as potential markers to identify high risk population for breast cancers. Flow cytometry data demonstrated that the Parsi benign and non-Parsi malignants have a higher number of cells labelled with these two prosomal protein antibodies than the non-Parsi benign and European 'normals'. Using immunohistochemical methods, p23 K was found to be significantly higher in Parsi and non-Parsi malignants as well as in non-Parsi benigns. In our FCM analysis, intergroup comparison showed, interestingly, a significantly higher expression of both p23K and p30.33K in Parsi benigns as compared to non-Parsis, raising the possibility that benign tumors of Parsis represent already premalignant lesions. The present study, in addition, proposes the prosomal antigens as likely cell proliferation markers comparable to Ki-67. 
%Z Copyright of this article belongs to PROFESSOR D A SPANDIDOS, EDITORIAL OFFICE, 1, S MERKOURI ST, ATHENS 116 35, GREECE.