TY  - JOUR
N1  - Copyright of this article belongs to PROFESSOR D A SPANDIDOS, EDITORIAL OFFICE, 1, S MERKOURI ST, ATHENS 116 35, GREECE.
ID  - open751
UR  - http://crdd.osdd.net/open/751/
IS  - 4
A1  - Bhui, AJ
A1  - Bureau, J
A1  - Abbas, A
A1  - Mondal, A
Y1  - 1996/10//
N2  - Epidemiological studies have revealed that Parsi women have a higher incidence of breast cancer than non-Parsis and that they are more susceptible to breast cancer. We have studied the cellular distribution of two prosomal proteins p23K in parallel to the p30.33K and proliferation marker Ki-67 as potential markers to identify high risk population for breast cancers. Flow cytometry data demonstrated that the Parsi benign and non-Parsi malignants have a higher number of cells labelled with these two prosomal protein antibodies than the non-Parsi benign and European 'normals'. Using immunohistochemical methods, p23 K was found to be significantly higher in Parsi and non-Parsi malignants as well as in non-Parsi benigns. In our FCM analysis, intergroup comparison showed, interestingly, a significantly higher expression of both p23K and p30.33K in Parsi benigns as compared to non-Parsis, raising the possibility that benign tumors of Parsis represent already premalignant lesions. The present study, in addition, proposes the prosomal antigens as likely cell proliferation markers comparable to Ki-67. 
PB  - PROFESSOR D A SPANDIDOS, EDITORIAL OFFICE, 1, S MERKOURI ST, ATHENS 116 35, GREECE 
JF  - INTERNATIONAL JOURNAL OF ONCOLOGY
VL  - 9
SN  - 1019-6439 
TI  - Novel cellular markers in breast cancer: Differential presence of p23K and p30.33K prosomal antigens in tumors of Parsi and non-Parsi women.
SP  - 669
AV  - none
EP  - 677
ER  -