@article{open763,
          volume = {17},
          number = {2},
          author = {P R Patnaik},
            note = {Copyright of this article belongs to Springer Science.},
           title = {Spectral analysis of the effect of inflow noise on a fed-batch fermentation for recombinant {\ensuremath{\beta}}-galactosidase},
       publisher = {Springer Science},
            year = {1997},
         journal = {Bioprocess Engineering},
           pages = {93},
             url = {http://crdd.osdd.net/open/763/},
        abstract = {The fermentative production of {\ensuremath{\beta}}-galactosidase from Escherichia coli CSH50 containing the plasmid pOU140 is mechanistically complex and difficult to model in a nonideal bioreactor. A spectral analysis has been done for a fed-batch fermentation with Gaussian disturbances in the feed stream. Inflow noise converts a smooth operation into aperiodic motion, as observed in some chemical reactions also. The disturbances also cause significant differences in the frequency responses of intra-cellular (plasmid DNA and {\ensuremath{\beta}}-galactosidase) and extra-cellular (concentration and mass fraction of recombinant cells) variables, whose implications are discussed.}
}