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primary topic: Proliferation markers and cell cycle associated expression of prosomes in breast cancers of Parsis and non-Parsis.

Proliferation markers and cell cycle associated expression of prosomes in breast cancers of Parsis and non-Parsis.
type: AcademicArticle
type: Article
abstract: The present study has focused attention essentially on the Parsis, an ethnic group with high breast cancer incidence. We have investigated the potential use of prosomes, compared to Ki-67 and PCNA, as an additional cell proliferation marker. We also addressed the question whether or not breast tumors of Parsis differed in their DNA index and in the proportion of the S-phase fraction, compared to that of non-Parsi and European patients. We observed that the benign tumors of Parsis and non-Parsis were hyperdiploids, whereas in case of malignant tumors the Parsis showed essentially diploid characteristics while hyperdiploidy prevailed in the non-Parsis. Tetraploidy was seen as a common feature in the non-Parsis, whereas aneuploidy seemed to be the more common type in the Parsis. The cell cycle analysis also revealed some interesting differences between the cell proliferation compartments of these two populations. A high number of cells in G2+M and S-phases was seen for non-Parsi malignant tumors while only the S-phase had a large cell count in the Parsis malignant tumors. The malignant tumors of Parsis and non-Parsis showed, as would be expected, a high expression of Ki-67 in the proliferation compartment. Surprisingly high Ki-67 expression was also a feature seen in the benign tumors of Parsis only and not any other group. We observed that expression of Ki-67, a proliferation marker directly related to the degree of malignancy, paralleled that of prosomal protein expression. In addition the prosomal monoclonal antibodies appeared to be more sensitive than Ki-67 in detecting a larger quantum of cells in the proliferation compartment.
date: 1997-08
volume: 11
issue: 2
is part of: International journal of oncology
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: RZ Other systems of medicine

Spandidos Publications Ltd.
type: Organization

International journal of oncology
type: Collection
issn: 10196439

K Scherrer
type: Person
given name: K
family name: Scherrer

J Bureau
type: Person
given name: J
family name: Bureau

V Parikh
type: Person
given name: V
family name: Parikh

A Mondal
type: Person
given name: A
family name: Mondal

AJ Bhui
type: Person
given name: AJ
family name: Bhui

A Therwath
type: Person
given name: A
family name: Therwath

R Kukreti
type: Person
given name: R
family name: Kukreti

HTML Summary of #773 Proliferation markers and cell cycle associated expression of prosomes in breast cancers of Parsis and non-Parsis.
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primary topic: Proliferation markers and cell cycle associated expression of prosomes in breast cancers of Parsis and non-Parsis.

RZ Other systems of medicine
type: Concept