%A G Das
%A H Vohra
%A B Saha
%A J N Agrewala
%A G C Mishra
%O Copyright of this article belongs to Wiley.
%J Clinical and Experimental Immunology
%T Apoptosis of Th1-like cells in experimental tuberculosis (TB)
%X Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-?) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.
%N 2
%K apoptosis, tuberculosis, Th1 cells, Fas, Bcl-2
%P 324-328
%V 115
%D 1999
%I Wiley
%R doi:10.1046/j.1365-2249.1999.00755.x
%L open797