@article{open804,
          volume = {35},
          number = {3-4},
          author = {P R Patnaik},
            note = {Copyright of this article belongs to Elsevier Science.},
           title = {Improvement of the microbial production of streptokinase by controlled filtering of process noise},
       publisher = {Elsevier Science},
            year = {1999},
         journal = {Process Biochemistry},
           pages = {309--315},
        keywords = {Streptokinase fermentation; Inflow noise; Process improvement; Controlled filtering},
             url = {http://crdd.osdd.net/open/804/},
        abstract = {Disturbances during operation are an ubiquitous feature of large-scale fermentations. This kind of process noise is often describable by a Gaussian distribution and is considered undesirable but unavoidable. In this paper, the fed-batch production of streptokinase (SK) was studied when such disturbances occurred in the inflow rate of the substrate. As the variance of the noise increased upto 6\% of the instantaneous value of the flowrate, there was a gradual improvement in the SK activity, after which the activity decreased for larger variances. The peak activity (10 850 U/ml) was 22\% higher than for a smooth noise-free feed. Similar earlier observations for {\ensuremath{\beta}}-galactosidase and {\ensuremath{\beta}}-lactamase suggest that normal disturbances may be harnessed to enhance fermentation efficiency by filtering them such that they are maintained within an optimal range.}
}