title: Improvement of the microbial production of streptokinase by controlled filtering of process noise
creator: Patnaik, P R
subject: QD Chemistry
description: Disturbances during operation are an ubiquitous feature of large-scale fermentations. This kind of process noise is often describable by a Gaussian distribution and is considered undesirable but unavoidable. In this paper, the fed-batch production of streptokinase (SK) was studied when such disturbances occurred in the inflow rate of the substrate. As the variance of the noise increased upto 6% of the instantaneous value of the flowrate, there was a gradual improvement in the SK activity, after which the activity decreased for larger variances. The peak activity (10 850 U/ml) was 22% higher than for a smooth noise-free feed. Similar earlier observations for β-galactosidase and β-lactamase suggest that normal disturbances may be harnessed to enhance fermentation efficiency by filtering them such that they are maintained within an optimal range.
publisher: Elsevier Science
date: 1999
type: Article
type: PeerReviewed
format: application/pdf
identifier: http://crdd.osdd.net/open/804/1/patnaik1999.1.pdf
relation: http://dx.doi.org/10.1016/S0032-9592(99)00073-4
identifier:   Patnaik, P R  (1999) Improvement of the microbial production of streptokinase by controlled filtering of process noise.  Process Biochemistry, 35 (3-4).  pp. 309-315.  ISSN 13595113     
relation: http://crdd.osdd.net/open/804/