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primary topic: Improvement of the microbial production of streptokinase by controlled filtering of process noise

Improvement of the microbial production of streptokinase by controlled filtering of process noise
type: AcademicArticle
type: Article
abstract: Disturbances during operation are an ubiquitous feature of large-scale fermentations. This kind of process noise is often describable by a Gaussian distribution and is considered undesirable but unavoidable. In this paper, the fed-batch production of streptokinase (SK) was studied when such disturbances occurred in the inflow rate of the substrate. As the variance of the noise increased upto 6% of the instantaneous value of the flowrate, there was a gradual improvement in the SK activity, after which the activity decreased for larger variances. The peak activity (10 850 U/ml) was 22% higher than for a smooth noise-free feed. Similar earlier observations for β-galactosidase and β-lactamase suggest that normal disturbances may be harnessed to enhance fermentation efficiency by filtering them such that they are maintained within an optimal range.
date: 1999
volume: 35
issue: 3-4
is part of: Process Biochemistry
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Improvement of the microbial production of streptokinase by controlled filtering of process noise (PDF)
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subject: QD Chemistry

Improvement of the microbial production of streptokinase by controlled filtering of process noise (PDF)
type: Document

Elsevier Science
type: Organization

Process Biochemistry
type: Collection
issn: 13595113

P R Patnaik
type: Person
given name: P R
family name: Patnaik

Improvement of the microbial production of streptokinase by controlled filtering of process noise (Image (PNG))
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Improvement of the microbial production of streptokinase by controlled filtering of process noise (Image (PNG))
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Improvement of the microbial production of streptokinase by controlled filtering of process noise (Image (PNG))
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Improvement of the microbial production of streptokinase by controlled filtering of process noise (Indexer Terms)
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primary topic: Improvement of the microbial production of streptokinase by controlled filtering of process noise

QD Chemistry
type: Concept