TY  - JOUR
ID  - open804
UR  - http://dx.doi.org/10.1016/S0032-9592(99)00073-4
IS  - 3-4
A1  - Patnaik, P R
N2  - Disturbances during operation are an ubiquitous feature of large-scale fermentations. This kind of process noise is often describable by a Gaussian distribution and is considered undesirable but unavoidable. In this paper, the fed-batch production of streptokinase (SK) was studied when such disturbances occurred in the inflow rate of the substrate. As the variance of the noise increased upto 6% of the instantaneous value of the flowrate, there was a gradual improvement in the SK activity, after which the activity decreased for larger variances. The peak activity (10?850 U/ml) was 22% higher than for a smooth noise-free feed. Similar earlier observations for ?-galactosidase and ?-lactamase suggest that normal disturbances may be harnessed to enhance fermentation efficiency by filtering them such that they are maintained within an optimal range.
VL  - 35
TI  - Improvement of the microbial production of streptokinase by controlled filtering of process noise
AV  - restricted
EP  - 315
N1  - Copyright of this article belongs to Elsevier Science.
Y1  - 1999///
PB  - Elsevier Science
JF  - Process Biochemistry
KW  - Streptokinase fermentation; Inflow noise; Process improvement; Controlled filtering
SN  - 13595113
SP  - 309
ER  -