creators_name: Patnaik, P R
type: article
datestamp: 2012-01-30 17:53:25
lastmod: 2015-01-09 10:32:41
metadata_visibility: show
title: Improvement of the microbial production of streptokinase by controlled filtering of process noise
ispublished: pub
subjects: QD
full_text_status: restricted
keywords: Streptokinase fermentation; Inflow noise; Process improvement; Controlled filtering
note: Copyright of this article belongs to Elsevier Science.
abstract: Disturbances during operation are an ubiquitous feature of large-scale fermentations. This kind of process noise is often describable by a Gaussian distribution and is considered undesirable but unavoidable. In this paper, the fed-batch production of streptokinase (SK) was studied when such disturbances occurred in the inflow rate of the substrate. As the variance of the noise increased upto 6% of the instantaneous value of the flowrate, there was a gradual improvement in the SK activity, after which the activity decreased for larger variances. The peak activity (10 850 U/ml) was 22% higher than for a smooth noise-free feed. Similar earlier observations for β-galactosidase and β-lactamase suggest that normal disturbances may be harnessed to enhance fermentation efficiency by filtering them such that they are maintained within an optimal range.
date: 1999
date_type: published
publication: Process Biochemistry
volume: 35
number: 3-4
publisher: Elsevier Science
pagerange: 309-315
id_number: doi:10.1016/S0032-9592(99)00073-4
refereed: TRUE
issn: 13595113
official_url: http://dx.doi.org/10.1016/S0032-9592(99)00073-4
related_url_url: http://www.sciencedirect.com/science/article/pii/S0032959299000734
related_url_type: pub
citation:   Patnaik, P R  (1999) Improvement of the microbial production of streptokinase by controlled filtering of process noise.  Process Biochemistry, 35 (3-4).  pp. 309-315.  ISSN 13595113     
document_url: http://crdd.osdd.net/open/804/1/patnaik1999.1.pdf