@article{open808,
          volume = {21},
          number = {2},
          author = {P R Patnaik},
            note = {Copyright of this article belongs to Sprinegr science.},
           title = {Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates},
       publisher = {Springer Science},
            year = {1999},
         journal = {Bioprocess Engineering},
           pages = {135},
             url = {http://crdd.osdd.net/open/808/},
        abstract = {When a microbe has a choice of two substrates for its growth in a fermentation medium, its preference varies with the substrates and with time. This "informed" choice is conveniently expressed by cybernetic models. For the growth of Klebsiella oxytoca in a medium of glucose and lactose, a one-parameter cybernetic model of growth has been employed in a batch bioreactor to analyse sensitivity of the fermentation to perturbations in the parameter, ! (0 h ! h 1). The sensitivity surfaces in the (!-time) space show interesting variations which are discussed. An important observation is that while growth is best promoted with !=1, i.e. sequential consumption of the substrates [8], low sensitivities require smaller values of !, i.e. simultaneous utilisation. Thus, in a realistic operation it may be necessary to compromise between high growth (with subsequent high productivity) and low sensitivity.
}
}