title: Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates
creator: Patnaik, P R
subject: QR Microbiology
description: When a microbe has a choice of two substrates for its growth in a fermentation medium, its preference varies with the substrates and with time. This "informed" choice is conveniently expressed by cybernetic models. For the growth of Klebsiella oxytoca in a medium of glucose and lactose, a one-parameter cybernetic model of growth has been employed in a batch bioreactor to analyse sensitivity of the fermentation to perturbations in the parameter, ! (0 h ! h 1). The sensitivity surfaces in the (!-time) space show interesting variations which are discussed. An important observation is that while growth is best promoted with !=1, i.e. sequential consumption of the substrates [8], low sensitivities require smaller values of !, i.e. simultaneous utilisation. Thus, in a realistic operation it may be necessary to compromise between high growth (with subsequent high productivity) and low sensitivity.  
publisher: Springer Science
date: 1999
type: Article
type: PeerReviewed
format: application/pdf
identifier: http://crdd.osdd.net/open/808/1/patnaik1999.3.pdf
relation: http://dx.doi.org/10.1007/s004490050653
identifier:   Patnaik, P R  (1999) Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates.  Bioprocess Engineering, 21 (2).  p. 135.  ISSN 0178515X     
relation: http://crdd.osdd.net/open/808/