TY  - JOUR
N1  - Copyright of this article belongs to Sprinegr science.
ID  - open808
UR  - http://dx.doi.org/10.1007/s004490050653
IS  - 2
A1  - Patnaik, P R
Y1  - 1999///
N2  - When a microbe has a choice of two substrates for its growth in a fermentation medium, its preference varies with the substrates and with time. This "informed" choice is conveniently expressed by cybernetic models. For the growth of Klebsiella oxytoca in a medium of glucose and lactose, a one-parameter cybernetic model of growth has been employed in a batch bioreactor to analyse sensitivity of the fermentation to perturbations in the parameter, ! (0 h ! h 1). The sensitivity surfaces in the (!-time) space show interesting variations which are discussed. An important observation is that while growth is best promoted with !=1, i.e. sequential consumption of the substrates [8], low sensitivities require smaller values of !, i.e. simultaneous utilisation. Thus, in a realistic operation it may be necessary to compromise between high growth (with subsequent high productivity) and low sensitivity.

PB  - Springer Science
JF  - Bioprocess Engineering
VL  - 21
SN  - 0178515X
TI  - Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates
AV  - restricted
ER  -