creators_name: Patnaik, P R
type: article
datestamp: 2012-01-31 08:44:03
lastmod: 2015-01-12 04:11:46
metadata_visibility: show
title: Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates
ispublished: pub
subjects: QR
full_text_status: restricted
note: Copyright of this article belongs to Sprinegr science.
abstract: When a microbe has a choice of two substrates for its growth in a fermentation medium, its preference varies with the substrates and with time. This "informed" choice is conveniently expressed by cybernetic models. For the growth of Klebsiella oxytoca in a medium of glucose and lactose, a one-parameter cybernetic model of growth has been employed in a batch bioreactor to analyse sensitivity of the fermentation to perturbations in the parameter, ! (0 h ! h 1). The sensitivity surfaces in the (!-time) space show interesting variations which are discussed. An important observation is that while growth is best promoted with !=1, i.e. sequential consumption of the substrates [8], low sensitivities require smaller values of !, i.e. simultaneous utilisation. Thus, in a realistic operation it may be necessary to compromise between high growth (with subsequent high productivity) and low sensitivity.

date: 1999
date_type: published
publication: Bioprocess Engineering
volume: 21
number: 2
publisher: Springer Science
pagerange: 135
id_number: doi:10.1007/s004490050653
refereed: TRUE
issn: 0178515X
official_url: http://dx.doi.org/10.1007/s004490050653
related_url_url: http://www.springerlink.com/content/1g1dettpfc1341fe/
related_url_type: pub
citation:   Patnaik, P R  (1999) Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates.  Bioprocess Engineering, 21 (2).  p. 135.  ISSN 0178515X     
document_url: http://crdd.osdd.net/open/808/1/patnaik1999.3.pdf