%0 Journal Article
%@ 0951208X
%A Patnaik, P R
%D 1999
%F open:813
%I http://www.springerlink.com/content/v03u6m3471339374/
%J Biotechnology Techniques
%K fermentation noise, �-galactosidase, neural control, neural filter
%N 11
%P 735-738
%T Coupling of a neural filter and a neural controller for improve-ment of fermentation performance
%U http://crdd.osdd.net/open/813/
%V 13
%X The noise associated with fermentation processes is normally minimised by a filtering technique. However, sometimes  the noise may be beneficial if it is properly regulated. For recombinant �-galactosidase production in a  fed-batch fermentation subject to Gaussian disturbances, it is shown that a neural network trained to act as a noise  filter can allow disturbances of only a particular variance which maximizes �-galactosidase synthesis. By coupling  such a filter with a neural controller, the productivity may be enhanced beyond what is possible with static filtering and either proportional-integral-derivative or neural control.
%Z Copyright of this article belongs to Springer Science.