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Bistability of Stationary States During Competition between Plasmid-Bearing and Plasmid-Free Cells under Selection Pressure
Feasibility and stability analyses have been carried out for the stationary states of a chemostat with recombinant microorganisms. In the absence of selection pressure, only a null state is possible, as expected. With selection pressure exerted by an antibiotic, either of two states may exist, according to the combination of dilution rate and inlet concentration. This is true for yeasts (S. cerevisiae) as well as bacteria (E. coli). However, too strong an antibiotic concentration kills all plasmid-free cells, thereby disallowing a non-trivial stationary state. Accounting for variation of the plasmid loss probability with the specific growth rate increases the stability regions. This is also possible by allowing a higher rate of segregational plasmid loss, implying that genetic stability may have to be balanced against reactor stability.
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QD Chemistry