%0 Journal Article
%@ 1471-2105
%A Raghava, G.P.S.
%A Searle, Stephen M J
%A Audley, Patrick C
%A Barber, Jonathan D
%A Barton, Geoffrey J
%D 2003
%F open:93
%I Biomedcentral
%J BMC bioinformatics
%P 47
%T OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy.
%U http://crdd.osdd.net/open/93/
%V 4
%X The OXBench suite of reference alignments, evaluation software and results database provide a convenient method to assess progress in sequence alignment techniques. Evaluation measures that were dependent on comparison to a reference alignment were found to give good discrimination between methods. The STAMP Sc Score which is independent of a reference alignment also gave good discrimination. Application of OXBench in this paper shows that with the exception of T-COFFEE, the majority of the improvement in alignment accuracy seen since 1985 stems from improved pair-score matrices rather than algorithmic refinements. The maximum theoretical alignment accuracy obtained by pooling results over all methods was 94.5% with 52.5% accuracy for alignments in the 0-10 percentage identity range. This suggests that further improvements in accuracy will be possible in the future.
%Z OPEN ACCESS