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primary topic: OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy.

OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy.
type: AcademicArticle
type: Article
abstract: The OXBench suite of reference alignments, evaluation software and results database provide a convenient method to assess progress in sequence alignment techniques. Evaluation measures that were dependent on comparison to a reference alignment were found to give good discrimination between methods. The STAMP Sc Score which is independent of a reference alignment also gave good discrimination. Application of OXBench in this paper shows that with the exception of T-COFFEE, the majority of the improvement in alignment accuracy seen since 1985 stems from improved pair-score matrices rather than algorithmic refinements. The maximum theoretical alignment accuracy obtained by pooling results over all methods was 94.5% with 52.5% accuracy for alignments in the 0-10 percentage identity range. This suggests that further improvements in accuracy will be possible in the future.
date: 2003-10-10
volume: 4
is part of: BMC bioinformatics
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy. (PDF)
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subject: QR Microbiology

OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy. (PDF)
type: Document
license: http://creativecommons.org/licenses/by/3.0/
has file: raghava2003.1.pdf
has part: raghava2003.1.pdf

Biomedcentral
type: Organization

BMC bioinformatics
type: Collection
issn: 14712105

Jonathan D Barber
type: Person
given name: Jonathan D
family name: Barber

G.P.S. Raghava
type: Person
given name: G.P.S.
family name: Raghava

Patrick C Audley
type: Person
given name: Patrick C
family name: Audley

Geoffrey J Barton
type: Person
given name: Geoffrey J
family name: Barton

Stephen M J Searle
type: Person
given name: Stephen M J
family name: Searle

OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy. (Image (PNG))
type: Document
is version of: OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy. (PDF)
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OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy. (Image (PNG))
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OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy. (Image (PNG))
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OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy. (Image (PNG))
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OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy. (Indexer Terms)
type: Document
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primary topic: OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy.

QR Microbiology
type: Concept