TY  - JOUR
N1  - OPEN ACCESS
ID  - open93
UR  - http://www.biomedcentral.com/content/pdf/1471-2105-4-47.pdf
A1  - Raghava, G.P.S.
A1  - Searle, Stephen M J
A1  - Audley, Patrick C
A1  - Barber, Jonathan D
A1  - Barton, Geoffrey J
Y1  - 2003/10/10/
N2  - The OXBench suite of reference alignments, evaluation software and results database provide a convenient method to assess progress in sequence alignment techniques. Evaluation measures that were dependent on comparison to a reference alignment were found to give good discrimination between methods. The STAMP Sc Score which is independent of a reference alignment also gave good discrimination. Application of OXBench in this paper shows that with the exception of T-COFFEE, the majority of the improvement in alignment accuracy seen since 1985 stems from improved pair-score matrices rather than algorithmic refinements. The maximum theoretical alignment accuracy obtained by pooling results over all methods was 94.5% with 52.5% accuracy for alignments in the 0-10 percentage identity range. This suggests that further improvements in accuracy will be possible in the future.
PB  - Biomedcentral
JF  - BMC bioinformatics
VL  - 4
SN  - 1471-2105
TI  - OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy.
AV  - public
ER  -