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primary topic: http://crdd.osdd.net/open/id/eprint/942

http://crdd.osdd.net/open/id/eprint/942
type: AcademicArticle
type: Article
title: Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway.
abstract: gamma-Glutamyl transpeptidase (gamma-GT) is the only enzyme known to be responsible for glutathione degradation in living cells. In the present study we provide evidence that the utilization of glutathione can occur in the absence of gamma-GT. When disruptions in the CIS2 gene encoding gamma-GT were created in met15Delta strains, which require organic sulfur sources for growth, the cells were able to grow well with glutathione as the sole sulfur source suggesting that a gamma-GT-independent pathway for glutathione degradation exists in yeast cells. The CIS2 gene was strongly repressed by ammonium and derepressed in glutamate medium, and was found to be regulated by the nitrogen regulatory circuit. The utilization of glutathione as a sulfur source was, however, independent of the nitrogen source in the medium, further underlining that the two degradatory pathways were distinct.
date: 2003-02-28
volume: 219
issue: 2
is part of: FEMS microbiology letters
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: http://crdd.osdd.net/open/id/document/3662
has version: http://crdd.osdd.net/open/id/document/3662
has published: http://crdd.osdd.net/open/id/document/3662
has document: http://crdd.osdd.net/open/id/document/3663
has document: http://crdd.osdd.net/open/id/document/3666
has document: http://crdd.osdd.net/open/id/document/3667
has document: http://crdd.osdd.net/open/id/document/3668
has document: http://crdd.osdd.net/open/id/document/3669
subject: QR Microbiology

http://crdd.osdd.net/open/id/document/3662
type: Document
label: Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. (PDF)

Elsevier/North Holland on behalf of the Federation of European Microbiological Societies.
type: Organization

FEMS microbiology letters
type: Collection
issn: 03781097

Chitranshu Kumar
type: Person
given name: Chitranshu
family name: Kumar

Rakesh Sharma
type: Person
given name: Rakesh
family name: Sharma

Anand K Bachhawat
type: Person
given name: Anand K
family name: Bachhawat

http://crdd.osdd.net/open/id/document/3663
type: Document
label: Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. (Indexer Terms)
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http://crdd.osdd.net/open/id/document/3666
type: Document
label: Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. (Image (PNG))
is version of: http://crdd.osdd.net/open/id/document/3662
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http://crdd.osdd.net/open/id/document/3667
type: Document
label: Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. (Image (PNG))
is version of: http://crdd.osdd.net/open/id/document/3662
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http://crdd.osdd.net/open/id/document/3668
type: Document
label: Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. (Image (PNG))
is version of: http://crdd.osdd.net/open/id/document/3662
is volatile version of: http://crdd.osdd.net/open/id/document/3662
ismedium thumbnail version of: http://crdd.osdd.net/open/id/document/3662

http://crdd.osdd.net/open/id/document/3669
type: Document
label: Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. (Image (PNG))
is version of: http://crdd.osdd.net/open/id/document/3662
is volatile version of: http://crdd.osdd.net/open/id/document/3662
issmall thumbnail version of: http://crdd.osdd.net/open/id/document/3662

http://crdd.osdd.net/open/942/
title: HTML Summary of #942 Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway.
format: text/html
primary topic: http://crdd.osdd.net/open/id/eprint/942

QR Microbiology
type: Concept