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primary topic: The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes.

The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes.
type: AcademicArticle
type: Article
abstract: The glutathione-mediated pathway for the detoxification of endogenously and exogenously derived toxic compounds was investigated using a pigment that accumulates in certain adenine biosynthetic mutants of yeasts. The ade1 / ade2 mutants of Saccharomyces cerevisiae, when grown on adenine-limiting medium, accumulate a characteristic red pigment (ade pigment) in their vacuoles. The precursors of the ade pigments are toxic intermediates that form conjugates with glutathione, followed by their transport inside the vacuole. In this study, this red pigment was used as a phenotypic screen to obtain insight regarding new genes involved in the three phases of this detoxification pathway: the activation phase (phase I), the conjugation phase (phase II), and the efflux phase (phase III). Components of the phase III (efflux) pathway which includes, in addition to the previously characterized Ycf1p and Bpt1p, another member of the 'Ycf1p family', Bat1p, as well as a vacuolar H(+)-ATPase-dependent transport were identified. In the investigation of phase II (conjugation), it was found that glutathione S-transferases, encoded by GTT1 and GTT2,do not appear to play a role in this process. By contrast, two other previously characterized genes, the oxidative stress transcription factor gene, SKN7, and the yeast caesin protein kinase gene, YCK1, of S. cerevisiae do participate in this pathway.
date: 2003-08
volume: 180
issue: 2
is part of: Archives of microbiology
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: http://crdd.osdd.net/open/id/document/3664
has version: http://crdd.osdd.net/open/id/document/3664
has published: http://crdd.osdd.net/open/id/document/3664
has document: http://crdd.osdd.net/open/id/document/3670
has document: http://crdd.osdd.net/open/id/document/3671
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has document: http://crdd.osdd.net/open/id/document/3673
has document: http://crdd.osdd.net/open/id/document/3674
subject: QR Microbiology

http://crdd.osdd.net/open/id/document/3664
type: Document
label: The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. (PDF)

Springer Science
type: Organization

Archives of microbiology
type: Collection
issn: 03028933

Anand K Bachhawat
type: Person
given name: Anand K
family name: Bachhawat

Rupinder Kaur
type: Person
given name: Rupinder
family name: Kaur

K G Sharma
type: Person
given name: K G
family name: Sharma

http://crdd.osdd.net/open/id/document/3670
type: Document
label: The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. (Indexer Terms)
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http://crdd.osdd.net/open/id/document/3671
type: Document
label: The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. (Image (PNG))
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http://crdd.osdd.net/open/id/document/3672
type: Document
label: The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. (Image (PNG))
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http://crdd.osdd.net/open/id/document/3673
type: Document
label: The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. (Image (PNG))
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http://crdd.osdd.net/open/id/document/3674
type: Document
label: The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. (Image (PNG))
is version of: http://crdd.osdd.net/open/id/document/3664
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http://crdd.osdd.net/open/943/
title: HTML Summary of #943 The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes.
format: text/html
primary topic: The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes.

QR Microbiology
type: Concept