{
      "subjects": [
        "QR"
      ],
      "eprintid": 970,
      "date": "2004-09-24",
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            "placement": 1,
            "eprintid": 970,
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      "official_url": "http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014579304010385",
      "keywords": "HLA-B27; Ankylosing spondylitis; Protein misfolding; Detailed molecular mechanism; MHC auto display; Autoimmune disorders",
      "pagerange": "1-8",
      "publisher": "Elsevier Science",
      "date_type": "published",
      "datestamp": "2012-02-14 12:16:00",
      "uri": "http:\/\/crdd.osdd.net\/open\/id\/eprint\/970",
      "publication": "FEBS letters",
      "abstract": "Expression of the MHC class I allele, HLA-B27, is correlated with autoimmune disease. The misfolding and association of B27 heavy chains through non-native disulfide bonds has recently been implicated. Here, we propose that beta2m-free, peptide-free heavy chains support a helix-coil transition in the segment leading from the alpha2 domain to the alpha3 domain, facilitating rotation of backbone angles around residues 167\/168, and allowing residues 169-181 (identical to a known B27 ligand) to loop around and occupy the molecule's own peptide-binding cleft. Such 'auto-display', occurring either within B27 molecules, or between B27 molecules, could provoke autoimmune attack.",
      "type": "article",
      "title": "HLA-B27 lacking associated beta2-microglobulin rearranges to auto-display or cross-display residues 169-181: a novel molecular mechanism for spondyloarthropathies.",
      "number": "1-3",
      "userid": 2,
      "issn": "0014-5793",
      "rev_number": 7,
      "dir": "disk0\/00\/00\/09\/70",
      "creators": [
        {
          "name": {
            "lineage": null,
            "given": "Manni",
            "honourific": null,
            "family": "Luthra-Guptasarma"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Balvinder",
            "honourific": null,
            "family": "Singh"
          }
        }
      ],
      "lastmod": "2012-02-14 12:16:00",
      "ispublished": "pub",
      "metadata_visibility": "show",
      "eprint_status": "archive",
      "status_changed": "2012-02-14 12:16:00",
      "volume": 575,
      "note": "Copyright of this article belongs to Elsevier Science.",
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          "url": "http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014579304010385",
          "type": "pub"
        }
      ],
      "refereed": "TRUE",
      "contact_email": "kps@imtech.res.in"
    }