The process of growth of new capillary blood vessels is used for healing and reproduction, which is known as angiogenesis. It occurs for healing wounds and for restoring blood flow to tissues after injury. The angiogenesis is controlled by producing inhibitory factors. The balance between pro-angiogenic molecules and anti-angiogenic molecules are hypothesized to regulate by an ‘on’ and the ‘off’, switch respectively. Angiogenesis-stimulating growth factors are “on switches” and the "off switches" are known as angiogenesis inhibitors. Recent studies have identified several endogenous anti-angiogenic peptides identified from various biological sources which regulate angiogenesis and tumor growth.
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