1DYQ	Enterotoxin	date	Feb 05, 2000
title	Staphylococcal Enterotoxin A Mutant Vaccine
authors	H.I.Krupka, B.W.Segelke, B.Rupp
compound		source
Molecule: Staphylococcal Enterotoxin A Mutant Chain: A Synonym: Sea Engineered: Yes Mutation: Yes		Organism_scientific: Staphylococcus Aureus Strain: A Expression_system: Escherichia Coli Expression_system_strain: Jm101 Expression_system_plasmid: Pse380 Expression_system_gene: Fda196e Other_details: Mutant Gene
symmetry	Space Group: P 21 21 21	R_factor	0.191
crystal cell	length a length b length c angle alpha angle beta angle gamma 39.048 78.652 86.374 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	1.50 Å
ligand	SO4, ZN	enzyme
note	1DYQ is a representative structure
related structures	by homologous chain: 1ESF
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subunit	Monomer.
subcellular loc.	Secreted protein.
Gene	ENTA (S. aureus)
function	The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene Ontology	Chain Function Process Component A zinc ion binding metal ion binding pathogenesis extracellular region
Primary reference	Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha., Krupka HI, Segelke BW, Ulrich RG, Ringhofer S, Knapp M, Rupp B, Protein Sci 2002 Mar;11(3):642-51. PMID:11847286

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (52 Kb) [Save to disk] Biological Unit Coordinates (1dyq.pdb1.gz) 49 Kb CSU: Contacts of Structural Units for 1DYQ Likely Quarternary Molecular Structure file(s) for 1DYQ Structure Factors (388 Kb) Retrieve 1DYQ in mmCIF format [Save to disk]

View 1DYQ in 3D

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Visual 3D analysis of 1DYQ

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Structure-derived information

Conformational Epitope Prediction for 1DYQ from the CEP Server. Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1DYQ, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1dyqa2, region A:121-233 [Jmol] [rasmolscript] [script source]     - Domain d1dyqa1, region A:6-120 [Jmol] [rasmolscript] [script source] Fold representative 1dyq from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1dyq_A]

Other resources with information on 1DYQ

InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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