1R6F	Protein Binding	date	Oct 15, 2003
title	The Structure Of Yersinia Pestis V-Antigen, An Essential Virulence Factor And Mediator Of Immunity Against Plague
authors	U.Derewenda, A.Mateja, Y.Devedjiev, K.M.Routzahn, A.G.Evdokimov, Z.S.Derewenda, D.S.Waugh
compound		source
Molecule: Virulence-Associated V Antigen Chain: A Fragment: Lcrv Fragment 24-323 Synonym: Low Calcium Response Locus Protein V Engineered: Yes Mutation: Yes		Organism_scientific: Yersinia Pestis Organism_common: Bacteria Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Bl21(De3)-Ril Expression_system_vector_type: Plasmid Expression_system_plasmid: Mbp-Lcrv(Delta1-23-C273s)-His6
symmetry	Space Group: P 1	R_factor	0.217
crystal cell	length a length b length c angle alpha angle beta angle gamma 35.881 45.086 46.915 76.20 78.42 77.17
method	X-Ray Diffraction	resolution	2.17 Å
note	1R6F is a representative structure
similarity	Belongs to the LcrV family.
subcellular loc.	Secreted protein.
Genes	ICRV, LCRV, Y0050, Y5047, YPCD1.31C (Y. pestis); YP (Y. pestis)
function	Possibly involved in calcium regulation of yop expression, which includes the export process.
Gene Ontology	Chain Function Process Component A pathogenesis extracellular region
Primary reference	The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague., Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS, Structure (Camb) 2004 Feb;12(2):301-6. PMID:14962390

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (46 Kb) [Save to disk] Biological Unit Coordinates (1r6f.pdb1.gz) 43 Kb CSU: Contacts of Structural Units for 1R6F Likely Quarternary Molecular Structure file(s) for 1R6F Structure Factors (99 Kb) Retrieve 1R6F in mmCIF format [Save to disk]

View 1R6F in 3D

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1R6F, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1r6fa_, region A [Jmol] [rasmolscript] [script source] Fold representative 1r6f from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1r6f_A]

Other resources with information on 1R6F

InterPro: IPR005413 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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